Clinical, functional, and inflammatory characteristics of asthma among adults aged over 60 years old: a case-control study.

ObjectiveThis observational case-control study analyzed the clinical, functional, inflammatory profile, and treatment data of a cohort of patients with asthma who were followed up at the outpatient clinic of a teaching hospital.MethodsPatients who visited the clinic between January 2008 and February 2020 and diagnosed with asthma according to the Global Initiative for Asthma (GINA) criteria were included in the study. Patients were broadly classified into two groups: age <60 or age ≥60 years. The patients were evaluated for asthma control and severity, medications used, comorbidities, smoking status, occurrence of exacerbation, spirometry at the first and last visits, sputum cytology, allergic prick test, and inflammatory cytokine levels.ResultsPatients over 60 years of age had lower asthma control test (ACT) scores, required higher doses of inhaled corticosteroids to achieve asthma control and had worse lung function with fixed airway obstruction, higher number of comorbidities, greater exposure to tobacco, and longer outpatient follow-up than younger patients with asthma. Furthermore, older patients presented with neutrophilia and higher levels of TNFα in the induced sputum as compared to younger patients.ConclusionsThese findings suggest that patients aged ≥60 years of age had a more severe asthma profile and poorer lung function than younger patients with asthma. Furthermore, aging, long-term asthma, comorbidities, and tobacco exposure contributed to an accelerated decline in lung function.

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer's Disease.

Alzheimer's disease (AD) is a complex multi-factorial neurodegenerative disorder for which only few drugs (including donepezil, DPZ) are available as symptomatic treatments; thus, researchers are focusing on the development of innovative multi-target directed ligands (MTDLs), which could also alter the course of the disease. Among other pathological factors, oxidative stress has emerged as an important factor in AD that could affect several pathways involved in the onset and progression of the pathology. Herein, we propose a new series of hybrid molecules obtained by linking a phenothiazine moiety, known for its antioxidant properties, with N-benzylpiperidine or N-benzylpiperazine fragments, mimicking the core substructure of DPZ. The investigation of the resulting hybrids showed, in addition to their antioxidant properties, their activity against some AD-related targets, such as the inhibition of cholinesterases (both AChE and BChE) and in vitro Aß1-40 aggregation, as well as the inhibition of the innovative target fatty acid amide hydrolase (FAAH). Furthermore, the drug-likeness properties of these compounds were assessed using cheminformatic tools. Compounds 11d and 12d showed the most interesting multi-target profiles, with all the assayed activities in the low micromolar range. In silico docking calculations supported the obtained results. Compound 13, on the other hand, while inactive in the DPPH assay, showed the best results in the in vitro antioxidant cell assays conducted on both HepG2 and SHSY-5Y cell lines. These results, paired with the low or absent cytotoxicity of these compounds at tested concentrations, allow us to aim our future research at the study of novel and effective drugs and pro-drugs with similar structural characteristics.

Bifunctional 3-Hydroxy-4-Pyridinones as Potential Selective Iron(III) Chelators: Solution Studies and Comparison with Other Metals of Biological and Environmental Relevance.

The binding ability of five bifunctional 3-hydroxy-4-pyridinones towards Cu2+ and Fe3+ was studied by means of potentiometric and UV-Vis spectrophotometric measurements carried out at I = 0.15 mol L-1 in NaCl(aq),T = 298.15 K and 310.15 K. The data treatments allowed us to determine speciation schemes featured by metal-ligand species with different stoichiometry and stability, owing to the various functional groups present in the 3-hydroxy-4-pyridinones structures, which could potentially participate in the metal complexation, and in the Cu2+ and Fe3+ behaviour in aqueous solution. Furthermore, the sequestering ability and metal chelating affinity of the ligands were investigated by the determination of pL0.5 and pM parameters at different pH conditions. Finally, a comparison between the Cu2+ and Fe3+/3-hydroxy-4-pyridinones data herein presented with those already reported in the literature on the interaction of Zn2+ and Al3+ with the same ligands showed that, from the thermodynamic point of view, the 3-hydroxy-4-pyridinones are particularly selective towards Fe3+ and could therefore be considered promising iron-chelating agents, also avoiding the possibility of competition, and eventually the depletion, of essential metal cations of biological and environmental relevance, such as Cu2+ and Zn2+.

Nevo epidérmico verrucoso inflamatório linear e diagnóstico diferencial com a psoríase linear: a respeito de um caso / Inflammatory linear verrucous epidermal nevus and differential diagnosis with linear psoriasis: about a case

Nevo epidérmico verrucoso inflamatório linear e diagnóstico diferencial com a psoríase linear: a respeito de um caso RELATO DE CASOMaria Isabel Muniz Zemero1, Maria Amélia Lopes dos Santos1, Alena Margareth Darwich Mendes1, Carla Andrea Avelar Pires1,O nevo epidérmico verrucoso inflamatório linear (NEVIL) é uma variedade clínica rara de nevo epidérmico verrucoso, que se manifesta no início da infância, como lesões inflamatórias de superfície ceratósica, que coalescem e se distribuem em faixa, acompanhando as linhas de Blaschko. Faz diagnóstico diferencial com a psoríase linear, sendo difícil a diferenciação, dado os aspectos clínicos e histopatológicos comuns aos dois, enfantizando-se a necessidade de conhecer as características específicas de cada um. O objetivo deste relato é demonstrar uma afecção relativamente rara, descrita em uma menina de 5 anos, evoluindo desde os primeiros dias de vida com placas papuloceratósicas dispostas linearmente, acompanhadas de sinais inflamatórios e áreas erosadas ocupando grandes lábios, períneo e face interna e superior da coxa esquerda. Também pápulas e placas ceratósicas na região cervical posterior e borda lateral externa da planta do pé esquerdo, ascendendo ao longo da região posterior deste membro. Os critérios clínicos e histopatológicos corroboram o diagnóstico de NEVIL na diferenciação com a psoríase linear, ressaltando a importância do estabelecimento de critérios/ ferramentas que auxiliem na diferenciação destas duas dermatoses visando agilizar o diagnóstico, otimizar o tratamento e minimizar o desconforto para esses pacientes. O acompanhamento a longo prazo dos portadores é sugerido pela possibilidade ainda que mínima de malignização do NEVIL. (AU)

Inflammatory linear verrucous epidermal nevus and differential diagnosis with linear psoriasis: about a caseCASE REPORTMaria Isabel Muniz Zemero1, Maria Amélia Lopes dos Santos1, Alena Margareth Darwich Mendes1, Carla Andrea Avelar Pires1,Inflammatory Linear Verrucous Epidermal Nevus (ILVEN) is a rare clinical variety of verrucous epidermal nevus that manifests in early childhood as inflammatory lesions of keratosis surface, which coalesce and spread in band, following Blaschko lines. It makes a differential diagnosis with Linear Psoriasis; it is difficult to differentiate them given the clinical and histopathological aspects common to both, emphasizing the need to know the specific characteristics of each. The purpose of this report is to demonstrate a relatively rare affection, expressed in a 5-year-old girl, evolving from the first days of life with papulokeratosic plaques arranged linearly, followed by inflammatory signs and eroded areas, placed linearly, overtaking labia majora, perineum, the inner and upper face of the left thigh. Also, the patient showed keratotic papules and plaques in the posterior cervical region and external lateral border of the left foot plant, ascending along the posterior region of this limb. The clinical and histopathological criteria corroborate the diagnosis of ILVEN in differentiation with linear psoriasis, emphasizing the importance of establishing criteria/instruments to assist in distinguishing these two dermatoses in order to expedite the diagnosis, to optimize the treatment and minimize patients' discomfort. Long-term follow-up of patients with this disease is suggested due to the possibility, albeit minimal, of ILVEN malignancy. (AU)

Cutaneous leishmaniasis mimicking cutaneous lymphoma.

Cutaneous leishmaniasis (CL) is caused by protozoa of Leishmania genus that are transmitted to humans through the bite of sand flies (Lutzomyia and Phlebotomus). The infection is classically manifested as multiple or single ulcers affecting cutaneous and/or mucosal areas of the body. Atypical lesions are relatively uncommon, being able to simulate a large variety of benign and malign dermatological disorders. In this article, we described a case of CL mimicking a clinical presentation of cutaneous lymphoma.

Bifunctional 3-hydroxy-4-pyridinones as effective aluminium chelators: synthesis, solution equilibrium studies and in vivo evaluation.

This paper reports the results on the study of a set of synthesized bifunctional 3-hydroxy-4-pyridinones chelators as potential aluminium sequestering agents. They were N-functionalized with alkyl-amino, -carboxylic and -(amino-carboxylic) groups, envisaging the improvement of the Al3+ sequestering capacity, in comparison with the marketed chelating drug deferiprone. The main focus of this work was given to the assessment of their binding ability towards Al3+, which was studied by potentiometric and UV-Vis spectrophotometric measurements carried out at T = 298.15 K. The speciation models were characterized by AlpLqHr(3p+r-qz) species with different stoichiometry. Depending on ligand side-chain structures and on their thermodynamic properties, different trends of stability was found. Furthermore, the sequestering ability of the ligands towards Al3+ was investigated by the calculation of pL0.5 values at different experimental conditions. These results clearly indicate that the presence of amino-carboxylic groups in the ligands increases the sequestering ability towards Al3+. The in silico evaluation of pharmacokinetic descriptors indicated no violation to the Lipinski's rule and drug-likeness properties. Furthermore, the in vivo bioassays on a model of metal-overload mice showed for three investigated ligands a higher metal-sequestering capacity than for the chelating drug deferiprone, thus suggesting their potential interest as Al-chelating drug candidates.

Câncer de pele: caracterização do perfil e avaliação da proteção solar dos pacientes atendidos em serviço universitário / Skin cancer: profile characterization and assessment to sun protection in patients of a college service

Introdução: O câncer de pele é a neoplasia de maior incidência no Brasil. Vários fatores têm sido atribuídos como risco para seu desenvolvimento, como: cor da pele, horário e tempo de exposição ao sol, residência em um país tropical e uso de imunossupressão crônica. Objetivo: descrever os casos de câncer de pele, bem como o hábito de proteção solar na prevenção de lesões causadas por radiação ultravioleta. Métodos: estudo transversal, individualizado e observacional com 50 pacientes, com diagnóstico de câncer de pele, acompanhados no Ambulatório de Dermatologia da Universidade do Estado do Pará, na cidade de Belém (PA), no período de janeiro de 2013 a outubro de 2016. A pesquisa foi feita por meio de um questionário padronizado autoaplicativo. Resultados: Observou-se o maior acometimento de câncer de pele em pacientes com idade > 50 anos (90%), brancos (68%), olhos castanhos (68%), cabelos castanhos (78%), que não faziam uso de filtro solar (86%); com diagnóstico de Carcinoma Basocelular (94%), tendo a face como a área corporal mais acometida (52%). Conclusões: O carcinoma Basocelular com lesões de mais de um ano de surgimento foi o câncer de pele predominante nesta população em que a maioria não apresentava o hábito do uso de filtro solar. (AU)

Introduction: Skin cancer is the cancer with the highest incidence in Brazil. Several factors have been assigned as a risk for its development, such as skin color, exposure time to the sun, living in a tropical country, making use of chronic immunosuppression. Objective: describe the cases of skin cancer and sun protection habits in preventing lesions caused by ultraviolet radiation. Methods: A cross-sectional, individuated and observational study with 50 patients, with the diagnosis of skin cancer accompanied at the dermatology clinic in the Pará State University, in Belém (PA), in the period of October 2016. Results: the greatest involvement of skin cancer was observed in patients with the following characteristics: age > 50 years (90%), White (68%), Brown eyes (68%), Brown hair (78%), did not use sunscreen (86%); as well as the predominance of Basal Cell Carcinoma in patients (94%), having the face as the most affected body area (52%. Conclusion: Basal Cell Carcinoma with lesions more than one year old was the predominant skin cancer in the population, in which the majority did not have the habit of using sunscreen. (AU)

IMPACT OF ATOPIC DERMATITIS ON THE QUALITY OF LIFE OF PEDIATRIC PATIENTS AND THEIR GUARDIANS. / IMPACTO DA DERMATITE ATÓPICA NA QUALIDADE DE VIDA DE PACIENTES PEDIÁTRICOS E SEUS RESPONSÁVEIS.

OBJECTIVE: To evaluate the impact of atopic dermatitis on the quality of life of pediatric patients in the age group of 5-16 years, and their parents, assisted at the Dermatology Department of Universidade do Estado do Pará in 2015. METHODS: A cross-sectional study including 51 patients and their guardians, to whom two questionnaires about the quality of life were applied, the Children's Dermatology Life Quality Index (CDLQI) and the Dermatitis Family Impact (DFI). To evaluate the severity of the disease, the researchers applied the Severity Scoring of Atopic Dermatitis (SCORAD) index. The Pearson Product-Moment Correlation Coefficient (PPMCC) evaluated the correlation between CDLQI, DFI, SCORAD, and the contingency coefficient C evaluated the association between the qualitative variables, considering p<0.05 significant. RESULTS: Of the patients, 55% were female. The average age was 9.5±3.2 years, and 41% had family income up ≤1 minimum wage. The average score was 5.4±5.1 for CDLQI, 6.6±4.5 for DFI, and 28.3±19.8 for SCORAD. The correlation among the scores CDLQI, DFI, and SCORAD was significant by the PPMCC (p<0,001). CONCLUSIONS: Atopic dermatitis affects the quality of life of both children and their guardians, and indicates the importance of including the study of quality of life as a complement to clinical evaluation.

OBJETIVO: Avaliar o impacto da dermatite atópica na qualidade de vida de pacientes pediátricos de 5 a 16 anos e seus responsáveis, atendidos no serviço de dermatologia da Universidade do Estado do Pará (UEPA) em 2015. MÉTODOS: Estudo transversal de 51 pacientes juntamente com seus responsáveis, aos quais foram aplicados dois questionários de qualidade de vida, o Escore da Qualidade de Vida na Dermatologia Infantil (CDLQI) e o Impacto da Dermatite Atópica na Família (DFI). Para avaliar a gravidade da doença, os pesquisadores aplicaram o índice de Severity Scoring of Atopic Dermatitis (SCORAD). A correlação linear de Pearson foi aplicada para averiguar a correspondência entre os instrumentos CDLQI, DFI e SCORAD, e o coeficiente de contingência C para avaliar a associação entre as variáveis qualitativas. Considerou-se significante p<0,05. RESULTADOS: Dos pacientes, 55% pertenciam ao sexo feminino. A idade média foi de 9.5±3.2 anos, e 41% tinha renda familiar de até um salário-mínimo. A média dos escores foi de 5.4±5.1 para o CDLQI, 6.6±4.5 para o DFI e 28.3±19.8 para o SCORAD. Atestou-se correlação altamente significante entre os escores CDLQI, DFI e SCORAD pela correlação linear de Pearson (p<0.001). CONCLUSÕES: A dermatite atópica afeta a qualidade de vida tanto das crianças quanto de seus responsáveis, o que indica a importância de inserir o estudo da qualidade de vida de forma complementar à avaliação clínica dos pacientes.

IMPACTO DA DERMATITE ATÓPICA NA QUALIDADE DE VIDA DE PACIENTES PEDIÁTRICOS E SEUS RESPONSÁVEIS / IMPACT OF ATOPIC DERMATITIS ON THE QUALITY OF LIFE OF PEDIATRIC PATIENTS AND THEIR GUARDIANS

RESUMO Objetivo: Avaliar o impacto da dermatite atópica na qualidade de vida de pacientes pediátricos de 5 a 16 anos e seus responsáveis, atendidos no serviço de dermatologia da Universidade do Estado do Pará (UEPA) em 2015. Métodos: Estudo transversal de 51 pacientes juntamente com seus responsáveis, aos quais foram aplicados dois questionários de qualidade de vida, o Escore da Qualidade de Vida na Dermatologia Infantil (CDLQI) e o Impacto da Dermatite Atópica na Família (DFI). Para avaliar a gravidade da doença, os pesquisadores aplicaram o índice de Severity Scoring of Atopic Dermatitis (SCORAD). A correlação linear de Pearson foi aplicada para averiguar a correspondência entre os instrumentos CDLQI, DFI e SCORAD, e o coeficiente de contingência C para avaliar a associação entre as variáveis qualitativas. Considerou-se significante p<0,05. Resultados: Dos pacientes, 55% pertenciam ao sexo feminino. A idade média foi de 9.5±3.2 anos, e 41% tinha renda familiar de até um salário-mínimo. A média dos escores foi de 5.4±5.1 para o CDLQI, 6.6±4.5 para o DFI e 28.3±19.8 para o SCORAD. Atestou-se correlação altamente significante entre os escores CDLQI, DFI e SCORAD pela correlação linear de Pearson (p<0.001). Conclusões: A dermatite atópica afeta a qualidade de vida tanto das crianças quanto de seus responsáveis, o que indica a importância de inserir o estudo da qualidade de vida de forma complementar à avaliação clínica dos pacientes.

ABSTRACT Objective: To evaluate the impact of atopic dermatitis on the quality of life of pediatric patients in the age group of 5-16 years, and their parents, assisted at the Dermatology Department of Universidade do Estado do Pará in 2015. Methods: A cross-sectional study including 51 patients and their guardians, to whom two questionnaires about the quality of life were applied, the Children’s Dermatology Life Quality Index (CDLQI) and the Dermatitis Family Impact (DFI). To evaluate the severity of the disease, the researchers applied the Severity Scoring of Atopic Dermatitis (SCORAD) index. The Pearson Product-Moment Correlation Coefficient (PPMCC) evaluated the correlation between CDLQI, DFI, SCORAD, and the contingency coefficient C evaluated the association between the qualitative variables, considering p<0.05 significant. Results: Of the patients, 55% were female. The average age was 9.5±3.2 years, and 41% had family income up ≤1 minimum wage. The average score was 5.4±5.1 for CDLQI, 6.6±4.5 for DFI, and 28.3±19.8 for SCORAD. The correlation among the scores CDLQI, DFI, and SCORAD was significant by the PPMCC (p<0,001). Conclusions: Atopic dermatitis affects the quality of life of both children and their guardians, and indicates the importance of including the study of quality of life as a complement to clinical evaluation.

Natural occurrence of Pasteuria nishizawae in soybean areas / Ocorrência natural de Pasteuria nishizawae em áreas de soja

Soybean (Glycine max (L.) Merrill) is a widely grown crop of economic prominence. Brazil is considered as the second largest worldwide producer and exporter. Soybean cyst nematode, Heterodera glycines Ichinohe, in one of the most serious threats for this crop, considered as its most destructive parasite. The first report of this disease in Brazil was recorded during the 1991/1992 harvest. Control of nematodes is more challenging if compared with other plant diseases control. Thus, there is a growing demand to search for alternative control practices that will not harm the environment nor the human being. Therefore, the highly specific bacteria Pasteuria spp. Metchnikoff, represents an auspicious biological control agent against nematodes. The biological control of the soybean cyst nematode with the bacterium Pasteuria nishizawae Sayre has proven an excellent choice and has been studied by different scientists. The objective of this work was to determine the natural occurrence of Pasteuria nishizawae in Brazilian soils. The experiment was performed under greenhouse conditions at the Research unit from Syngenta® in Uberlandia-MG, Brazil, with soil samples originated from soybean planted areas from the Brazilian states of Bahia, Goiás, Mato Grosso and Paraná. Fractions of 150 cm3 of soil were withdrawn to be processed by the centrifugal flotation technique in sucrose solution. Aliquots of 1 mL from the obtained suspension were observed in Peters' chamber with the aid of an inverted light microscope, in order to verify the absence or presence of bacterial endospores attached to the cuticle of the nematodes extracted from the soil samples. The frequency of Pasteuria nishizawae incidence was of 100% within the samples analyzed.

A soja (Glycine max (L.) Merrill) é uma cultura de grande importância econômica. O Brasil é o segundo maior produtor e exportador mundial. Um dos mais sérios problemas fitossanitários desta cultura é o nematoide do cisto, Heterodera glycines Ichinohe, considerado o parasito mais destrutivo. A primeira ocorrência desta doença no Brasil foi relatada na safra 1991/1992. O controle de nematoides é mais difícil quando comparado com outras doenças. Torna-se cada vez mais importante a busca de controle alternativo, que não ofereça risco ao meio ambiente e nem ao aplicador. Sendo assim, a bactéria Pasteuria spp. Metchnikoff com alta especificidade, representa um promissor agente de controle biológico dos nematoides. O controle biológico do nematoide do cisto da soja pela bactéria Pasteuria nishizawae Sayre vem sendo estudado por diversos pesquisadores. O objetivo deste trabalho foi determinar a ocorrência natural de Pasteuria nishizawae em solos brasileiros. O ensaio foi conduzido em casa-de-vegetação na Unidade de Pesquisa da Syngenta em Uberlândia ­ MG, com amostras de solo provenientes de áreas de cultivo de soja dos estados brasileiros Bahia, Goiás, Mato Grosso e Paraná. Foram retiradas uma alíquota de 150 cm3 de solo e então a mesma foi processada pela técnica da flotação centrífuga em solução de sacarose. Da suspensão obtida foi observada uma alíquota de 1 mL em câmara de Peters, com o auxílio do microscópio invertido, verificando a presença ou ausência de endósporos da bactéria aderidos na cutícula dos nematoides extraídos. A frequência de ocorrência da Pasteuria nishizawae foi de 100% nas amostras analisadas.

An NMR study on the 6,6'-(2-(diethylamino)ethylazanediyl)bis(methylene)bis(5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) interaction with Al(III) and Zn(II) ions.

Here we report about the complex formation among an amine-bearing bis-kojic acid, 6,6'-(2-(diethylamino)ethylazanediyl)bis(methylene)bis(5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) and two metal ions, the trivalent hard and not essential metal ion Al(III) and the borderline and essential divalent metal ion Zn(II). We carried out a thorough NMR study in order to reach the indispensable structural information on the behavior of these complexes in solution. A combination of 1D, 2D total correlation spectroscopy, heteronuclear single quantum coherence spectroscopy, nuclear Overhauser enhancement spectroscopy and rotating-frame Overhauser effect spectroscopy experiments was used to assign the signals of both free and metal-bound ligand at different pH values. Our results highlighted the different coordination behaviors of the ligand towards the different metal ions, depending on their hard or borderline character. The trivalent metal ion, Al(III), mainly forms dinuclear helicate complexes of M2L3 stoichiometry, and the coordination only involves both hydroxypyrone (O,O)-donor atoms. NMR data are in agreement with the presence of a rigid and symmetric structure of L9-Al(III) complexes up to physiological pH. On the contrary, with the divalent metal ion, NMR data showed the coexistence of several species in solution though Zn(II) forms complexes of ML stoichiometry at physiological pH, where the metal coordination involves the nitrogen atoms of both the linker and the side-chain amine groups together with the oxygen atoms of phenolate groups. The in solution study will be of interest for providing an insight on the ligand bioavailability and on its behavior in the chelation treatments.

Pyoderma gangrenosum in a newborn--case report.

Pyoderma gangrenosum is a rare, inflammatory, chronic and recurrent disease of unknown etiology, characterized by noninfectious, necrotizing and painful cutaneous ulcers. Usually it affects adults aged between 25 and 54 years old and rarely children (less than 4%), in which it mainly affects the head, face, buttocks, genital and perianal region. The disease presents a quick response to systemic corticosteroids. We report a case of a newborn with hemorrhagic and necrotic ulcers, distributed in the abdomen, buttocks and genital region with rapid and effective response to oral prednisone.

Pyoderma gangrenosum in a newborn - case report / Pioderma gangrenoso em recem - nascido - relato de caso

Pyoderma gangrenosum is a rare, inflammatory, chronic and recurrent disease of unknown etiology, characterized by noninfectious, necrotizing and painful cutaneous ulcers. Usually it affects adults aged between 25 and 54 years old and rarely children (less than 4%), in which it mainly affects the head, face, buttocks, genital and perianal region. The disease presents a quick response to systemic corticosteroids. We report a case of a newborn with hemorrhagic and necrotic ulcers, distributed in the abdomen, buttocks and genital region with rapid and effective response to oral prednisone.

O Pioderma gangrenoso é uma doença inflamatória rara, crônica e recorrente, de etiopatogenia desconhecida, caracterizada por uma ulceração não-infecciosa, necrotizante e dolorosa da pele. Geralmente, afeta adultos na faixa de 25 a 54 anos e raramente crianças (menos de 4%), nestes acomete preferencialmente cabeça e face, nádegas, região perianal e genital. Apresenta rápida resposta à corticoterapia sistêmica. Relata-se um caso de recém-nascida com lesões ulceradas de pioderma gangrenoso de fundo hemorrágico e necrótico distribuídas em abdômen, região genital e glútea com resposta rápida e efetiva à prednisona oral.

Perfil clínico-epidemiológico de pacientes com psoríase / Clinical and epidemiological profile of psoriasis patients

Objetivo: determinar o perfil clínico-epidemiológico dos portadores de psoríase atendidos, durante o ano de 2009 no Ambulatório de Dermatologia da UEPA, Belém-Pa. Método: estudo transversal, no qual foram entrevistados 50 pacientes portadores da doença. A entrevista baseou-se em um protocolo composto de uma parte inicial com perguntas relacionadas ao perfil sócio-econômico e aos aspectos relativos a fatores associados com doença em estudo e uma parte subseqüente, na qual foram avaliados aspectos da apresentação clínica da psoríase. Resultados: verificou-se que predominou o sexo feminino, faixa etária de 38 a 48 anos de idade, com ensino fundamental incompleto e que afirmaram estar passando por alguma situação estressante na época do surgimento da doença. Predominou a psoríase em placa, disseminada e os membros inferiores foi a localização mais acometida. Conclusão: é de grande importância o incentivo de pesquisas que visem delinear o perfil clínico-epidemiológico, a fim de se conhecer melhor as populações que são atingidas por esta dermatose no Brasil.

Objective: was to determine clinical and epidemiological profile of patients with psoriasis treated during the year of 2009 in UEPA Dermatology Clinic, Belém-Pa-Brazil. Methods: It was performed a transversal and prospective study, in which 50 patients with the disease were interviewed. The interview was based on a protocol that included in its initial portion questions related to socio-economic profile and aspects related to factors associated with the disease under study and a subsequent part, in which analyze psoriasis clinical presentation.Results: It was found that most patients were female, aged between 38 to 48 years-old, with incomplete basic education and they said they were going through some stressful situation at the time of disease onset. The predominant clinical presentation was disseminated plaque psoriasis and lower limbs was the most affected location. Conclusions: It is very important the incentive for research aimed at delineating clinical and epidemiological profile, in order to better understand people who are suffering from this dermatosis in Brazil.

Soil microbial response to glucose and phosphorus addition under agricultural systems in the Brazilian Cerrado.

Conventional tillage (CT) and no-tillage (NT) management systems alter soil nutrient availability and consequently modify soil microbial response to nutrient additions such as carbon (C) and phosphorus (P). The objective of this study is to evaluate microbial response to the addition of C (glucose) and P (Na2HPO4.7H2O) under CT and NT in the brazilian Cerrado. In response to glucose addition, the NT system yielded higher microbial respiration rates and glucose consumption than the CT system. The best microbial response to C addition was after 0 - 12 h incubation in NT and 0 - 24 h in CT. The addition of P produced higher demand under CT than NT. After incubation, biochemical indicators such as microbial respiration, glucose consumption, dehydrogenase activity and metabolic yield confirmed the higher glucose demands under NT and higher phosphorus demands under CT. These results demonstrate that C and P addition alter significantly the microbial response, suggesting that soil microorganisms present nutrient differential demands between CT and NT management systems.

Reação de acessos de feijoeiro a nematóides de galhas / Reation of resistance in common bean to root-knot nematodes

Neste trabalho, 54 acessos de feijoeiro foram caracterizados incluindo as fontes de resistência (Nemasnap e Manoa Wonder) e seis linhagens de tomateiro e uma de soja, como testemunhas. Foram utilizadas seis repetições, sendo inoculadas com 3.000 ovos das seguintes espécies e raças: Meloidogyne incognita raças 1, 2, 3 e 4, M. javanica e M. paranaensis. Confirmou-se a resistência das fontes Nemasnap e Manoa Wonder às espécies e raças do gênero Meloidogyne estudadas (M. incognita raça 1, 2, 3, 4, M. javanica e M. paranaensis) pelo fator de reprodução. Somente IPA 5 foi resistente às cinco populações de nematóides estudadas, exceto M. incognita raça 4. No entanto as cultivares Diamante negro, Varressai, Goitacazes, Carioca-MG, Bambuí, Rudá, Pérola, Macotaco, FT 120, IAPAR31, IAPAR 64 e IAPAR 72, mostraram-se resistentes a essa raça tanto pelo fator de reprodução como pelas notas. Jalo precoce, Ouro branco, IPA 10, Bambuí, Rudá, Jalo Eep 558, IAPAR 57, IAPAR 65 e IAPAR 72 foram resistentes à Meloidogyne paranaensis.

In this study, fifty four acess of common bean were characterized including the sources of resistance (Nemasnap and Manoa Wonder) and 06 lines of tomato and soybean, as control. We used six replicates, and inoculated with 3000 eggs and breed the following species: Meloidogyne incognita race 1, 2, 3 and 4, M. javanica and M. paranaensis. Showed the strength of sources and Manoa Wonder, Nemasnap species and races of the genus Meloidogyne studied (M. incognita race 1, 2, 3, 4, M. javanica and M. paranaensis) by the reproduction factor. The cultivars Diamante Negro, Varressai, Goitacazes, Carioca-MG, Bambuí, Rudá, Pérola, Macotaco, FT 120, IAPAR31, IAPAR 64 and IAPAR 72 were resistant to M. incognita races by factor of reproduction. Jalo precoce, Ouro Branco, IPA 10, Bambuí, Rudá, Jalo Eep 558, IAPAR 57, IAPAR 65 and IAPAR 72 were resistant to Meloidogyne paranensis. IAPAR 57, IAPAR 72 and Bambuí were resistance to all species studied in this work

Produção cientifica de enfermagem na perspectiva do controle da infecção hospitalar / Scientific production of nursing in perspective from control of hospital infection

Objetivos: analisar a produção cientifica nacional da enfermagem sobre infecção hospitalar, com a finalidade de avaliar oimpacto da portaria MS-196/83, quantificar essa produção nas diferentes décadas e listar as principais medidas deprevenção e controle. Metodologia: realizou-se levantamento bibliográfico manual, no período de 1980 a 2006, emrevistas brasileiras de enfermagem do acervo da Biblioteca Central da Universidade de São Paulo. Resultados: totalizou-se33 publicações de enfermagem sobre infecção hospitalar; o período de 2000 a 2006 concentra o maior número detrabalhos nesta área temática. Evidenciando participação de 65% de docentes na produção cientifica. Observamos oelevado número de publicações com objeto de estudo Legislação, ética e CCIH 13 (40%) as quais enfatizam o papelrelevante do enfermeiro no contexto de infecção hospitalar e a importância da atuação da Comissão de Controle deInfecção Hospitalar, e o elevado percentual de estudos descritivos/exploratório, procurando a mudança decomportamento e controle da infecção hospitalar. Conclusão: o combate às infecções hospitalares apresenta-se hojecomo um problema complexo. Reconhecemos que embora a temática infecção hospitalar seja muito freqüente eamplamente divulgada, na enfermagem nacional ainda é pouco abordada.

Evaluation of diagnostic criteria for severe asthma described in a public health directive regulating the free distribution of medications for the maintenance treatment of asthma.

OBJECTIVE: To evaluate the capacity of the criteria described in Complementary Directive SAS/MS 12, issued on November 12, 2002, to identify patients with severe asthma, describing and comparing clinical, functional and treatment data of such patients. METHODS: This was a nested case-control study using a structured database for adult asthma outpatients. We defined cases as asthma patients who met the inclusion criteria described in the directive, defining controls as those who did not. We collected and compared data related to the following: demographic characteristics; history of asthma; medications in use; comorbidities; history of tobacco use; number of exacerbations within the last 12 months, asthma-related hospitalizations and intensive care unit admissions within the last 12 months; spirometry; and sputum cytology. RESULTS: The case and control groups consisted of 29 and 31 patients, respectively. The number of asthma exacerbations and emergence room visits within the last 12 months, as well as the number of patients that received at least one pulse of oral corticosteroids, was significantly higher in the case group than in the control group. In addition, prebronchodilator FVC was lower among the cases than among the controls. Furthermore, cytology revealed that eosinophil counts were significantly higher in the induced sputum of cases than in that of controls. CONCLUSIONS: The criteria described in the directive are suited to stratifying patients with severe asthma.

Avaliação dos descritores de asma grave em pacientes incluídos na portaria de saúde pública que regulamenta a distribuição gratuita de medicamentos para o tratamento de manutenção da asma / Evaluation of diagnostic criteria for severe asthma described in a public health directive regulating the free distribution of medications for the maintenance treatment of asthma

OBJETIVO: Avaliar a capacidade dos critérios descritos na Portaria Complementar SAS/MS nº12, de 12 de novembro de 2002, em identificar pacientes asmáticos graves, bem como descrever e comparar dados clínicos, funcionais e de tratamento destes pacientes. MÉTODOS: Estudo caso-controle aninhado em um banco de dados estruturado de atendimento ambulatorial de asmáticos. Foram considerados casos os pacientes asmáticos que preencheram os critérios de inclusão determinados na portaria e considerados controles os que não preencheram os mesmos critérios. Foram coletados e comparados dados demográficos; história pregressa da asma; medicamentos em uso; presença de comorbidades; história de tabagismo; presença, no último ano, de exacerbações, de hospitalizações e de admissões em unidades de terapia intensiva devido à asma; e resultados de espirometria e de citologia de escarro. RESULTADOS: Foram incluídos 29 e 31 pacientes, respectivamente, nos grupos caso e controle. O grupo caso apresentou maior número de exacerbações e maior número de visitas ao pronto-socorro no último ano, maior porcentagem de pacientes que receberam pelo menos um pulso de corticosteroide oral, assim como menores valores de CVF pré-broncodilatador em relação ao grupo controle. O grupo caso também apresentou um aumento significante de eosinófilos na citologia do escarro induzido. CONCLUSÕES: Os critérios de inclusão descritos na portaria são adequados para estratificar pacientes com asma grave.

OBJECTIVE: To evaluate the capacity of the criteria described in Complementary Directive SAS/MS 12, issued on November 12, 2002, to identify patients with severe asthma, describing and comparing clinical, functional and treatment data of such patients. METHODS: This was a nested case-control study using a structured database for adult asthma outpatients. We defined cases as asthma patients who met the inclusion criteria described in the directive, defining controls as those who did not. We collected and compared data related to the following: demographic characteristics; history of asthma; medications in use; comorbidities; history of tobacco use; number of exacerbations within the last 12 months, asthma-related hospitalizations and intensive care unit admissions within the last 12 months; spirometry; and sputum cytology. RESULTS: The case and control groups consisted of 29 and 31 patients, respectively. The number of asthma exacerbations and emergence room visits within the last 12 months, as well as the number of patients that received at least one pulse of oral corticosteroids, was significantly higher in the case group than in the control group. In addition, prebronchodilator FVC was lower among the cases than among the controls. Furthermore, cytology revealed that eosinophil counts were significantly higher in the induced sputum of cases than in that of controls. CONCLUSIONS: The criteria described in the directive are suited to stratifying patients with severe asthma.

Efeito de broncodilatador através das câmaras de suspensäo "Jet" e "Fisonair" / Bronchodilating effect with two spacer devices: Jet and Fisonair

Vinte pacientes com obstruçäo reversível ao fluxo aéreo foram avaliados de modo cruzado em dias diferentes quanto à resposta ao salbutamol 200 mcg, administrado por diferentes câmaras de expansäo: Jet (103 ml) e grande câmara de suspensäo Fisonair (750 ml). Houve maior aumento da resposta com Fisonair: 0,32L comparado com Jet: 0,26L (p = 0,02). A resposta com Jet foi 21 por cento menor (IC: -7 a -35 por cento).